The Settings screen allows the admin to configure all the general and payment settings for the WordPress eStore plugin (eg. shopping cart currency, language etc).
Please see the Payment Gateway Settings page for payment related settings option.
General Settings
Email Notification and Digital Product Delivery Settings
WP eStore Email Settings
The email settings allows the admin configure various email related options (eg. email body, from address etc)
Testing and Debugging Settings
All the settings fields have help text explaining what the particular field does.